Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2194654 | 1.00 | AKR1B10 (0.40) | AKR1B10AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL2192222 | 0.85 | MAPT (0.44) | SMN1; SMN2FFAR1KDM4EMEN1KMT2A | |
| SCHEMBL2192220 | 0.85 | MAPT (0.44) | SMN1; SMN2FFAR1KDM4EMEN1KMT2A | |
| SCHEMBL2194186 | 0.82 | HDAC2 (0.38) | NPC1RAB9APOLBCYP2C9 | |
| SCHEMBL3245417 | 0.79 | MEN1 (0.49) | AKR1B10AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL3245411 | 0.79 | MEN1 (0.49) | AKR1B10AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL3510820 | 0.77 | KDM4E (0.39) | SMN1; SMN2FFAR1KDM4EMEN1KMT2A | |
| SCHEMBL3510825 | 0.77 | KDM4E (0.39) | SMN1; SMN2FFAR1KDM4EMEN1KMT2A | |
| SCHEMBL13211382 | 0.77 | MAPT (0.53) | AKR1B10AKR1B1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL27892114 | 0.77 | AKR1B10 (0.43) | AKR1B10AKR1B1AKR1C4AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172245-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172245-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | BRAF, NRAS, RAF1 | AKR1B10 1636/4885AKR1B1 1856/4885AKR1C4 1596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.