AKR1B10

Aldo-keto reductase family 1 member B10 · O60218 · AKR1B10 on Sugi Atlas →

72,578 patent compounds predicted against AKR1B10, 56,009 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Benzyl Cinnamate (SCHEMBL43212)	0.84	7/20
Benzyl Cinnamate (SCHEMBL43213)	0.84	7/20
SCHEMBL144597	0.65	7/20
SCHEMBL144598	0.65	7/20
SCHEMBL43817	0.59	7/20
SCHEMBL47328	0.51	7/20
Phenethyl Cinnamate (SCHEMBL43631)	1.00	6/20
Phenethyl Cinnamate (SCHEMBL43632)	1.00	6/20
Propyl Cinnamate (SCHEMBL133146)	0.69	6/20
Propyl Cinnamate (SCHEMBL133147)	0.69	6/20
SCHEMBL81835	0.63	6/20
SCHEMBL81836	0.63	6/20
Hydrochloric Acid (SCHEMBL143254)	0.63	6/20
Hydrochloric Acid (SCHEMBL143255)	0.63	6/20
SCHEMBL116997	0.50	6/20
Caffeic Acid Phenethyl Ester (SCHEMBL93649)	1.00	5/20
SCHEMBL149407	0.72	5/20
SCHEMBL112365	0.61	5/20
SCHEMBL112366	0.61	5/20
Chlorogenic Acid (SCHEMBL19466)	1.00	4/20

Clinical trials — most relevant to AKR1B10 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
ALL SCTped FORUM - Pharmacogenomic Study (add-on Study)	PHASE4	UNKNOWN
The Role of CYP8B1 Polymorphisms in Modulating the Biochemical Pathways Affected by SGLT2 Inhibitors in T2DM and Obesity	PHASE4	COMPLETED
The Role of Mineralocorticoid Receptors in Vascular Function	PHASE2/PHASE3	COMPLETED
Toxicity and Efficacy Evaluation of Topical Minoxidil in Acne Vulgaris	PHASE1/PHASE2	UNKNOWN
A Phase Ib/II Clinical Study on AK112 Combined or Not Combined With AK119 in pMMR/MSS Colorectal Cancer	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
A Phase Ib/II Clinical Study of AK127 in Combination With AK112 in Patients With Advanced Solid Tumors	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
A Study of AK146D1 for Injection in the Treatment of Advanced Solid Tumors	PHASE1	RECRUITING
A Study of AK146D1 for Injection in Advanced Solid Tumors	PHASE1	RECRUITING
Tolerability of Enteral NAC in Infants	PHASE1	NOT_YET_RECRUITING
Biomarkers in Bone Marrow and Blood Samples From Patients With Prostate Cancer Treated With Ketoconazole	nan	WITHDRAWN
Adrenoleukodystrophy National Registry Study	nan	RECRUITING
5-Alpha Reductase 2 as a Marker of Resistance to 5ARI Therapy	nan	RECRUITING
Tissue Predictors of Abiraterone Benefit	nan	COMPLETED
Gene Polymorphisms Influencing Steroid Synthesis and Action	nan	WITHDRAWN
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
EndoNAFLD: Relationship Between Fatty Liver Disease and Cardiovascular Diseases	nan	COMPLETED
A Study of Genetic Influence on LDL Hyper-responsiveness in Patients Following a Ketogenic Diet	nan	RECRUITING
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages	nan	COMPLETED
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Evaluation of Hydroxymethylbutyrate Supplementation in Lung Transplant Candidates Receiving Pulmonary Rehabilitation	nan	COMPLETED
Intraprostatic Androgenicity in Relation to Circulating Levels of Hormones and Polymorphisms of Hormone-Related Genes: A Methodologic Study	nan	COMPLETED
Pharmacogenetics of Alcohol: Treatment Implications	nan	COMPLETED
The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (REFUEL PCOS) Study 2	nan	UNKNOWN
ALDH2 Genetic Testing in East Asian Community	nan	NOT_YET_RECRUITING
A Prospective Observational Study of Biomarkers for a Personalised IVF Treatment	nan	UNKNOWN
A Pilot Study of Varying Doses of Tamoxifen in the Setting of Genetic Polymorphisms of CYP2D6	nan	COMPLETED
Genetic Association of Diabetic Retinopathy-1	nan	UNKNOWN
Exercise Capacity, Physical Fitness, and Physical Activity Levels in Children With CAH	nan	COMPLETED
Blood Pressure Control in Juveniles - Longitudinal Study	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a AKR1B10 binder may also engage these)

Protein	Name	Similarity
P21300	—	1.000	P21300 →
P45376	—	1.000	P45376 →
P16116	—	0.999	P16116 →
P80276	—	0.998	P80276 →
C9JRZ8	—	0.998	C9JRZ8 →
O08782	—	0.997	O08782 →
Q8VCX1	—	0.996	Q8VCX1 →
Q28FD1	—	0.995	Q28FD1 →
Q5RJP0	—	0.995	Q5RJP0 →
P15122	—	0.993	P15122 →
P45377	—	0.993	P45377 →
P07943	—	0.992	P07943 →
AKR1A1	Aldo-keto reductase family 1 member A1	0.991	landscape →
M9PF61	—	0.991	M9PF61 →
Q9TV64	—	0.991	Q9TV64 →
P82125	—	0.991	P82125 →
AKR1D1	Aldo-keto reductase family 1 member D1	0.990	landscape →
Q6GMC7	—	0.990	Q6GMC7 →
P31210	—	0.990	P31210 →
Q9DCT1	—	0.989	Q9DCT1 →
Q5ZK84	—	0.988	Q5ZK84 →
Q3ZCJ2	—	0.987	Q3ZCJ2 →
P17264	—	0.986	P17264 →
Q5U1Y4	—	0.986	Q5U1Y4 →
AKR1B1	Aldo-keto reductase family 1 member B1	0.986	landscape →
O70473	—	0.985	O70473 →
P02532	—	0.985	P02532 →
Q6IMN8	—	0.984	Q6IMN8 →
Q5R5D5	—	0.984	Q5R5D5 →
Q6AZW2	—	0.984	Q6AZW2 →