Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.64 |
| ▸ | LCK | P06239 | 16/20 | 0.64 |
| ▸ | EGFR | P00533 | 12/20 | 0.64 |
| ▸ | BTK | Q06187 | 13/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23484941 | 0.93 | JAK3 (0.71) | JAK3LCKEGFRBTK | |
| SCHEMBL21946363 | 0.92 | JAK3 (0.72) | JAK3LCKEGFRBTK | |
| SCHEMBL30448210 | 0.92 | JAK3 (0.72) | JAK3LCKEGFRBTK | |
| SCHEMBL26970114 | 0.92 | JAK3 (0.65) | JAK3LCKEGFRBTK | |
| SCHEMBL21946318 | 0.87 | LCK (0.59) | JAK3LCKEGFRBTK | |
| SCHEMBL31039906 | 0.87 | LCK (0.59) | JAK3LCKEGFRBTK | |
| SCHEMBL21855164 | 0.87 | LCK (0.59) | JAK3LCKEGFRBTK | |
| SCHEMBL24927490 | 0.87 | LCK (0.59) | JAK3LCKEGFRBTK | |
| SCHEMBL21946361 | 0.85 | JAK3 (0.68) | JAK3LCKEGFRBTK | |
| SCHEMBL30448986 | 0.85 | JAK3 (0.68) | JAK3LCKEGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |