Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 12/20 | 0.59 |
| ▸ | BTK | Q06187 | 7/20 | 0.59 |
| ▸ | JAK3 | P52333 | 14/20 | 0.55 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | CCNK | O75909 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | CCND3 | P30281 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.50 |
| ▸ | CKS1B | P61024 | 1/20 | 0.49 |
| ▸ | SKP1 | P63208 | 1/20 | 0.49 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21946318 | 1.00 | LCK (0.59) | LCKBTKJAK3EGFRSYK | |
| SCHEMBL21855164 | 1.00 | LCK (0.59) | LCKBTKJAK3EGFRSYK | |
| SCHEMBL24927490 | 1.00 | LCK (0.59) | LCKBTKJAK3EGFRSYK | |
| SCHEMBL21946907 | 0.91 | LCK (0.54) | LCKBTKJAK3EGFR | |
| SCHEMBL21946911 | 0.91 | LCK (0.54) | LCKBTKJAK3EGFRSYK | |
| SCHEMBL28637618 | 0.91 | BTK (0.62) | LCKBTKJAK3EGFRSYK | |
| SCHEMBL21946753 | 0.90 | CKS1B (0.48) | LCKBTKJAK3EGFRSYK | |
| SCHEMBL23484941 | 0.87 | JAK3 (0.71) | LCKBTKJAK3EGFR | |
| SCHEMBL21946347 | 0.87 | JAK3 (0.56) | LCKBTKJAK3EGFR | |
| SCHEMBL21946887 | 0.87 | JAK3 (0.64) | LCKBTKJAK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118955473-A | Difunctional compounds for degrading BTK via the ubiquitin proteasome pathway | 紐力克斯治疗公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-113412259-B | Difunctional compounds for degrading BTK via the ubiquitin proteasome pathway | 紐力克斯治疗公司 | 2024-07-16 | — | — | CN | disclosed |