Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.53 |
| ▸ | CTSC | P53634 | 2/20 | 0.52 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9179033 | 0.86 | CTSC (0.53) | RENCTSCCALCRLBACE1 | |
| SCHEMBL30038268 | 0.85 | CALCRL (0.56) | RENCTSCCALCRLPSMB5BACE1 | |
| SCHEMBL18568248 | 0.85 | CALCRL (0.56) | RENCTSCCALCRLBACE1 | |
| SCHEMBL9642398 | 0.85 | CALCRL (0.56) | RENCTSCCALCRLBACE1 | |
| SCHEMBL8953885 | 0.85 | CALCRL (0.56) | RENCTSCCALCRLBACE1 | |
| SCHEMBL30053097 | 0.84 | CTSC (0.57) | RENCTSCCALCRLPSMB5BACE1 | |
| SCHEMBL29958630 | 0.83 | REN (0.58) | RENCTSCPSMB5 | |
| SCHEMBL30239995 | 0.83 | CTSC (0.52) | RENCTSCCALCRLBACE1 | |
| SCHEMBL30638996 | 0.83 | REN (0.50) | RENCALCRLBACE1 | |
| SCHEMBL30186417 | 0.82 | CTSC (0.55) | RENCTSCCALCRLBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190070251-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NEKTAR THERAPEUTICS | 2019-03-07 | — | — | US | disclosed |
| US-9682153-B2 | Polymer conjugates of therapeutic peptides | NEKTAR THERAPEUTICS (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160022828-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NEKTAR THERAPEUTICS | 2016-01-28 | — | — | US | disclosed |
| US-20110171312-A1 | MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE | NEKTAR THERAPEUTICS (US) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022828-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NGLY1, CD44, IAPP | REN 2640/4885CTSC 331/4885CALCRL 2145/4885 |
| US-20190070251-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NGLY1, CD44, IAPP | REN 2640/4885CTSC 331/4885CALCRL 2145/4885 |
| US-20110171312-A1 | MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE | DNPEP, VIP, PTMS | REN 1551/4885CTSC 157/4885CALCRL 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.