SCHEMBL2194718

SCHEMBL2194718

N=C(N)NCCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CS)C(=O)NC[C]=O

nearest known ligand 0.62

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NPY4R P50391 19/20 0.62
NPY1R P25929 12/20 0.62
NPY5R Q15761 10/20 0.62
NPY2R P49146 8/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8565859 0.89 NPY4R (0.62) NPY4RNPY1RNPY5RNPY2R
SCHEMBL8565851 0.89 NPY4R (0.62) NPY4RNPY1RNPY5RNPY2R
SCHEMBL2194622 0.88 NPY4R (0.62) NPY4RNPY1RNPY5RNPY2R
SCHEMBL29962209 0.88 NPY4R (0.64) NPY4RNPY1RNPY5RNPY2R
SCHEMBL2191389 0.87 NPY4R (0.55) NPY4RNPY1RNPY5RNPY2R
SCHEMBL30668288 0.86 NPY4R (0.67) NPY4RNPY1RNPY5RNPY2R
SCHEMBL2193850 0.86 NPY4R (0.58) NPY4RNPY1RNPY5RNPY2R
SCHEMBL31679355 0.86 NPY4R (0.62) NPY4RNPY1RNPY5RNPY2R
SCHEMBL29932214 0.85 NPY4R (0.63) NPY4RNPY1RNPY5RNPY2R
SCHEMBL31305854 0.85 NPY4R (0.57) NPY4RNPY1RNPY5RNPY2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8680263-B2 Carbohydrate-based drug delivery polymers and conjugates thereof NEKTAR THERAPEUTICS (US) 2014-03-25 US disclosed
US-20110171716-A1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF NEKTAR THERAPEUTICS (US) 2011-07-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110171716-A1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF STT3B, STT3A, DDOST NPY4R 2480/4885NPY1R 3329/4885NPY5R 3577/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.