Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 4/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23192139 | 1.00 | CTSL (0.43) | CTSLCTSBCTSKNAAATMEM97 | |
| SCHEMBL22614076 | 0.78 | CTSL (0.46) | CTSLCTSBCTSKNAAATMEM97 | |
| SCHEMBL31212210 | 0.78 | CTSL (0.46) | CTSLCTSBCTSKNAAATMEM97 | |
| SCHEMBL20121044 | 0.77 | CTSL (0.45) | CTSLCTSBCTSKNAAATMEM97 | |
| SCHEMBL24437601 | 0.77 | EPHX2 (0.47) | CTSLCTSBCTSKNAAATMEM97 | |
| SCHEMBL20121045 | 0.77 | CTSL (0.45) | CTSLCTSBCTSKNAAATMEM97 | |
| SCHEMBL29284867 | 0.77 | CTSL (0.45) | CTSLCTSBCTSKNAAATMEM97 | |
| SCHEMBL29260378 | 0.75 | CTSL (0.50) | CTSLCTSBCTSKNAAATMEM97 | |
| SCHEMBL2633999 | 0.74 | EPHX2 (0.51) | CTSLCTSBCTSKEPHX2TSHR | |
| SCHEMBL2634094 | 0.74 | EPHX2 (0.51) | CTSLCTSBCTSKEPHX2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081508-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-04-23 | — | — | WO | disclosed |