Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.61 |
| ▸ | LCK | P06239 | 18/20 | 0.61 |
| ▸ | BTK | Q06187 | 7/20 | 0.50 |
| ▸ | EGFR | P00533 | 8/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25603500 | 0.83 | JAK3 (0.69) | JAK3LCKBTKEGFR | |
| SCHEMBL18296292 | 0.79 | BTK (0.55) | JAK3LCKBTKEGFR | |
| SCHEMBL28653352 | 0.78 | JAK3 (0.85) | JAK3LCKBTKEGFR | |
| SCHEMBL16763828 | 0.77 | JAK3 (1.00) | JAK3LCKBTKEGFR | |
| SCHEMBL16763871 | 0.77 | JAK3 (1.00) | JAK3LCKBTKEGFR | |
| SCHEMBL21946880 | 0.76 | JAK3 (0.70) | JAK3LCKBTKEGFR | |
| SCHEMBL25598953 | 0.76 | JAK3 (0.70) | JAK3LCKBTKEGFR | |
| SCHEMBL18296315 | 0.74 | PLAU (0.43) | BTK | |
| SCHEMBL21946311 | 0.71 | JAK3 (0.77) | JAK3LCKBTKEGFR | |
| SCHEMBL21946322 | 0.70 | JAK3 (0.76) | JAK3LCKBTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |