Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.55 |
| ▸ | JAK3 | P52333 | 4/20 | 0.55 |
| ▸ | LCK | P06239 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.44 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18296315 | 0.82 | PLAU (0.43) | BTKMAP4K4PTPN11IKBKB | |
| SCHEMBL25603500 | 0.79 | JAK3 (0.69) | BTKJAK3LCKEGFR | |
| SCHEMBL21947699 | 0.79 | JAK3 (0.61) | BTKJAK3LCKEGFR | |
| SCHEMBL18296266 | 0.77 | CAMK1D (0.43) | BTKJAK3LCKEGFRPIM1 | |
| SCHEMBL18296430 | 0.76 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL22346873 | 0.76 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL22346882 | 0.76 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL29871745 | 0.76 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL18296094 | 0.76 | JAK3 (0.67) | BTKJAK3LCKEGFR | |
| SCHEMBL22359274 | 0.75 | BTK (0.53) | BTKJAK3LCKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |