Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 4/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21946392 | 0.86 | KDM1A (0.39) | KDM1AGNAI3GNAO1GNAI1ATM | |
| SCHEMBL21947714 | 0.84 | PAOX (0.47) | KDM1AGNAI3GNAO1GNAI1ATM | |
| SCHEMBL24220815 | 0.81 | GAA (0.44) | ALDH1A1MAPTLMNA | |
| SCHEMBL24926155 | 0.79 | HTR7 (0.38) | GNAI3GNAO1GNAI1ATMHTR1A | |
| SCHEMBL11490504 | 0.78 | CYP1A2 (0.55) | KDM1AATMCXCR4ALDH1A1MAPT | |
| SCHEMBL14417850 | 0.75 | ATM (0.47) | GNAI3GNAO1GNAI1ATMITGB3 | |
| SCHEMBL11489916 | 0.75 | KDM1A (0.48) | KDM1AATMITGB3ITGA2BCXCR4 | |
| SCHEMBL4236957 | 0.73 | PAOX (0.56) | CXCR4ALDH1A1LMNANPC1HRH2 | |
| SCHEMBL19047579 | 0.73 | KDM1A (0.52) | KDM1AGNAI3GNAO1GNAI1ATM | |
| SCHEMBL8185716 | 0.72 | PHGDH (0.47) | KDM1AGNAI3GNAO1GNAI1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021113557-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2021-06-10 | — | — | WO | disclosed |
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |