Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 9/20 | 0.47 |
| ▸ | PIM1 | P11309 | 8/20 | 0.47 |
| ▸ | PRKACA | P17612 | 8/20 | 0.47 |
| ▸ | CDK2 | P24941 | 8/20 | 0.47 |
| ▸ | HIPK2 | Q9H2X6 | 8/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 7/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 7/20 | 0.47 |
| ▸ | PAK4 | O96013 | 7/20 | 0.47 |
| ▸ | FLT3 | P36888 | 7/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 7/20 | 0.47 |
| ▸ | CLK2 | P49760 | 7/20 | 0.47 |
| ▸ | CDK7 | P50613 | 7/20 | 0.47 |
| ▸ | CDK9 | P50750 | 7/20 | 0.47 |
| ▸ | PRKX | P51817 | 7/20 | 0.47 |
| ▸ | JAK3 | P52333 | 7/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 7/20 | 0.47 |
| ▸ | STK3 | Q13188 | 7/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 7/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21964836 | 0.89 | CDC7 (0.49) | CDC7PIM1PRKACACDK2HIPK2 | |
| SCHEMBL21960691 | 0.88 | TYK2 (0.55) | TYK2 | |
| SCHEMBL21961849 | 0.88 | TYK2 (0.55) | TYK2 | |
| SCHEMBL21948561 | 0.88 | TYK2 (0.55) | TYK2 | |
| SCHEMBL21948298 | 0.88 | TYK2 (0.55) | TYK2 | |
| SCHEMBL21948982 | 0.86 | CDC7 (0.49) | CDC7PIM1PRKACACDK2HIPK2 | |
| SCHEMBL20688009 | 0.84 | KDM4E (0.47) | CDC7PIM1PRKACACDK2HIPK2 | |
| SCHEMBL20689109 | 0.83 | TYK2 (0.59) | TYK2 | |
| SCHEMBL21948049 | 0.82 | TYK2 (0.62) | TYK2 | |
| SCHEMBL20689447 | 0.80 | TYK2 (0.63) | TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081508-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-04-23 | — | — | WO | disclosed |