Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 6/20 | 0.49 |
| ▸ | CDK2 | P24941 | 5/20 | 0.49 |
| ▸ | PIM1 | P11309 | 4/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.49 |
| ▸ | PRKACA | P17612 | 3/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.49 |
| ▸ | TYK2 | P29597 | 4/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21964836 | 0.94 | CDC7 (0.49) | CDC7CDK2PIM1ROCK2PRKACA | |
| SCHEMBL20688009 | 0.89 | KDM4E (0.47) | CDC7CDK2PIM1ROCK2PRKACA | |
| SCHEMBL21948564 | 0.86 | CDC7 (0.47) | CDC7CDK2PIM1ROCK2PRKACA | |
| SCHEMBL21961849 | 0.83 | TYK2 (0.55) | TYK2 | |
| SCHEMBL21948298 | 0.83 | TYK2 (0.55) | TYK2 | |
| SCHEMBL21948561 | 0.83 | TYK2 (0.55) | TYK2 | |
| SCHEMBL21960691 | 0.83 | TYK2 (0.55) | TYK2 | |
| SCHEMBL20689592 | 0.83 | TYK2 (0.67) | TYK2 | |
| SCHEMBL21948058 | 0.82 | KDM4E (0.47) | CDC7CDK2PIM1ROCK2PRKACA | |
| SCHEMBL20697458 | 0.81 | TYK2 (0.56) | TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081508-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-04-23 | — | — | WO | disclosed |