Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | ESRRG | P62508 | 4/20 | 0.33 |
| ▸ | ESRRB | O95718 | 3/20 | 0.33 |
| ▸ | ESR1 | P03372 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4385966 | 0.93 | HRH3 (0.43) | HRH3SLC18A3ESRRGESRRBESR1 | |
| SCHEMBL4377751 | 0.86 | CCR2 (0.36) | CYP1A2ESRRGESRRBESR1KCNH2 | |
| SCHEMBL23175630 | 0.84 | CYP1A2 (0.53) | HRH3CYP1A2LMNAMAPT | |
| SCHEMBL10218782 | 0.84 | CYP1A2 (0.53) | HRH3CYP1A2LMNAMAPT | |
| SCHEMBL20088214 | 0.82 | ESRRG (0.35) | HRH3ESRRGESRRBESR1KCNH2 | |
| SCHEMBL25124985 | 0.82 | HRH3 (0.47) | HRH3KCNH2SIGMAR1 | |
| SCHEMBL4374290 | 0.81 | HRH3 (0.45) | HRH3KCNH2LMNAMEN1MAPT | |
| SCHEMBL31273027 | 0.81 | HRH3 (0.47) | HRH3CYP1A2SLC18A3KCNH2CYP2D6 | |
| SCHEMBL31272933 | 0.81 | HRH3 (0.47) | HRH3CYP1A2SLC18A3KCNH2SIGMAR1 | |
| SCHEMBL20088224 | 0.77 | ESRRG (0.34) | HRH3ESRRGESRRBESR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3640248-A1 | AMINOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Beijing Adamadle Biotechnology Limited Liability Company (CN) | 2020-04-22 | — | — | EP | disclosed |