Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 9/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SHBG | P04278 | 1/20 | 0.44 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | VDR | P11473 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MDM4 | O15151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30786280 | 1.00 | GPBAR1 (0.54) | GPBAR1LMNAHSD17B10CYP2C9CYP3A4 | |
| SCHEMBL27241191 | 1.00 | GPBAR1 (0.54) | GPBAR1LMNAHSD17B10CYP2C9CYP3A4 | |
| SCHEMBL22018106 | 1.00 | GPBAR1 (0.54) | GPBAR1LMNAHSD17B10CYP2C9CYP3A4 | |
| SCHEMBL27241193 | 1.00 | GPBAR1 (0.54) | GPBAR1LMNAHSD17B10CYP2C9CYP3A4 | |
| SCHEMBL21955546 | 1.00 | GPBAR1 (0.54) | GPBAR1LMNAHSD17B10CYP2C9CYP3A4 | |
| SCHEMBL21955547 | 1.00 | GPBAR1 (0.54) | GPBAR1LMNAHSD17B10CYP2C9CYP3A4 | |
| SCHEMBL3192871 | 0.87 | GPBAR1 (0.72) | GPBAR1LMNAHSD17B10CYP2C9CYP3A4 | |
| SCHEMBL13324310 | 0.87 | GPBAR1 (0.72) | GPBAR1LMNAHSD17B10CYP2C9CYP3A4 | |
| SCHEMBL3192865 | 0.87 | GPBAR1 (0.72) | GPBAR1LMNAHSD17B10CYP2C9CYP3A4 | |
| SCHEMBL29618946 | 0.87 | GPBAR1 (0.72) | GPBAR1LMNAHSD17B10CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658566-B1 | SIDE-CHAIN MODIFIED ERGOSTEROL AND STIGMASTEROL DERIVATIVES AS LIVER X RECEPTOR MODULATORS | OSPEDALE SAN RAFFAELE SRL (IT) | 2023-07-19 | — | — | EP | disclosed |
| US-20200157135-A1 | SIDE-CHAIN MODIFIED ERGOSTEROL AND STIGMASTEROL DERIVATIVES AS LIVER X RECEPTOR MODULATORS | OSPEDALE SAN RAFFAELE SRL (IT) | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157135-A1 | SIDE-CHAIN MODIFIED ERGOSTEROL AND STIGMASTEROL DERIVATIVES AS LIVER X RECEPTOR MODULATORS | NR1H3, NR1H2, CYP27A1 | GPBAR1 47/4885LMNA 3124/4885HSD17B10 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.