Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 6/20 | 0.59 |
| ▸ | BTK | Q06187 | 3/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 4/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.47 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21958727 | 1.00 | TEAD1 (0.59) | TEAD1BTKEPHX2TP53MEN1 | |
| SCHEMBL21958740 | 0.94 | TEAD1 (0.53) | TEAD1BTKEPHX2TP53MEN1 | |
| SCHEMBL12184249 | 0.86 | EPHX2 (0.56) | EPHX2TP53MEN1KMT2ASLC6A2 | |
| SCHEMBL10607268 | 0.86 | EPHX2 (0.59) | BTKEPHX2TP53MEN1KMT2A | |
| SCHEMBL25785238 | 0.85 | BTK (0.49) | TEAD1BTKEPHX2MEN1KMT2A | |
| SCHEMBL2636858 | 0.84 | EPHX2 (0.54) | BTKEPHX2TP53MEN1KMT2A | |
| SCHEMBL2636860 | 0.83 | EPHX2 (0.53) | BTKEPHX2TP53MEN1KMT2A | |
| SCHEMBL9900709 | 0.82 | USP30 (0.56) | EPHX2TP53MEN1KMT2ASLC6A2 | |
| SCHEMBL9903075 | 0.82 | EPHX2 (0.65) | EPHX2TP53MEN1KMT2ASLC6A2 | |
| SCHEMBL22446295 | 0.81 | TEAD1 (0.49) | TEAD1BTKEPHX2TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |