Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 9/20 | 0.55 |
| ▸ | RHOC | P08134 | 2/20 | 0.51 |
| ▸ | RHOA | P61586 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | BTK | Q06187 | 4/20 | 0.48 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
| ▸ | SPR | P35270 | 1/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21958158 | 1.00 | TEAD1 (0.55) | TEAD1RHOCRHOAEGFRBTK | |
| SCHEMBL21958157 | 0.92 | TEAD1 (0.60) | TEAD1RHOCRHOAEGFRBTK | |
| SCHEMBL21958183 | 0.92 | TEAD1 (0.60) | TEAD1RHOCRHOAEGFRBTK | |
| SCHEMBL25785369 | 0.86 | TEAD1 (0.55) | TEAD1RHOCRHOAEGFRBTK | |
| SCHEMBL21958156 | 0.84 | TEAD1 (0.53) | TEAD1EGFRBTK | |
| SCHEMBL24780719 | 0.83 | TEAD1 (0.71) | TEAD1EGFRBTKDCUN1D1 | |
| SCHEMBL21957254 | 0.83 | TEAD1 (0.71) | TEAD1EGFRBTKDCUN1D1 | |
| SCHEMBL21958163 | 0.83 | TEAD1 (0.71) | TEAD1EGFRBTKDCUN1D1 | |
| SCHEMBL21958764 | 0.82 | EGFR (0.55) | TEAD1EGFRBTK | |
| SCHEMBL21958166 | 0.82 | EGFR (0.55) | TEAD1EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |