Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 5/20 | 0.49 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.49 |
| ▸ | PRKACA | P17612 | 4/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.49 |
| ▸ | PIM1 | P11309 | 3/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20688009 | 0.85 | KDM4E (0.47) | CDC7CDK2ROCK2PRKACAHIPK2 | |
| SCHEMBL21948058 | 0.78 | KDM4E (0.47) | CDC7CDK2ROCK2PRKACAHIPK2 | |
| SCHEMBL21964836 | 0.77 | CDC7 (0.49) | CDC7CDK2ROCK2PRKACAHIPK2 | |
| SCHEMBL20697424 | 0.77 | KMT2A (0.48) | CDK2MEN1KMT2AATMMAPT | |
| SCHEMBL21948982 | 0.75 | CDC7 (0.49) | CDC7CDK2ROCK2PRKACAHIPK2 | |
| SCHEMBL20689484 | 0.75 | KDM4E (0.45) | CDC7CDK2ROCK2PRKACAHIPK2 | |
| SCHEMBL20689336 | 0.75 | KDM4E (0.45) | CDK2MEN1KMT2AATMMAPT | |
| SCHEMBL22252351 | 0.74 | CDC7 (0.44) | CDC7CDK2ROCK2PRKACAHIPK2 | |
| SCHEMBL21961843 | 0.74 | KDM4E (0.47) | CDC7CDK2ROCK2PRKACAHIPK2 | |
| SCHEMBL21961725 | 0.74 | KDM4E (0.49) | CDK2MEN1KMT2AATMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200131201-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200131201-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | CDC7 621/4885CDK2 342/4885ROCK2 246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.