Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.45 |
| ▸ | CASP1 | P29466 | 3/20 | 0.45 |
| ▸ | CASP7 | P55210 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17781277 | 0.86 | KDM4E (0.53) | KDM4ENPC1RAB9AHSD17B10ALDH1A1 | |
| SCHEMBL22105271 | 0.84 | KDM4E (0.54) | KDM4ENPC1RAB9AHSD17B10ALDH1A1 | |
| SCHEMBL21961702 | 0.82 | CCNA2 (0.45) | KDM4ENPC1RAB9AHSD17B10ALDH1A1 | |
| SCHEMBL19680296 | 0.81 | KDM4E (0.55) | KDM4ENPC1RAB9AHSD17B10ALDH1A1 | |
| SCHEMBL25117830 | 0.79 | ALDH1A1 (0.62) | KDM4ENPC1RAB9AHSD17B10ALDH1A1 | |
| SCHEMBL20697060 | 0.79 | KDM4E (0.64) | KDM4ENPC1RAB9AHSD17B10ALDH1A1 | |
| SCHEMBL21961705 | 0.79 | KDM4E (0.51) | KDM4ENPC1RAB9AHSD17B10ALDH1A1 | |
| SCHEMBL2801191 | 0.77 | KDM4E (0.66) | KDM4ENPC1RAB9AHSD17B10ALDH1A1 | |
| SCHEMBL8184450 | 0.77 | KDM4E (0.49) | KDM4ENPC1RAB9AHSD17B10ALDH1A1 | |
| SCHEMBL22820298 | 0.76 | KDM4E (0.45) | KDM4ENPC1RAB9AHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200131201-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200131201-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | KDM4E 391/4885NPC1 4595/4885RAB9A 3462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.