SCHEMBL21962425

SCHEMBL21962425

CS(=O)(=O)c1cccc(C(=O)c2cnc(N3CCNCC3)s2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 1/20 0.46
HDAC2 Q92769 10/20 0.44
HDAC1 Q13547 6/20 0.44
HDAC3 O15379 8/20 0.43
HDAC4 P56524 4/20 0.43
HDAC7 Q8WUI4 4/20 0.43
HDAC10 Q969S8 4/20 0.43
HDAC11 Q96DB2 4/20 0.43
HDAC8 Q9BY41 4/20 0.43
HDAC6 Q9UBN7 4/20 0.43
HDAC9 Q9UKV0 4/20 0.43
HDAC5 Q9UQL6 4/20 0.43
ACVR1 Q04771 1/20 0.43
CHRM3 P20309 1/20 0.42
CYP1A2 P05177 1/20 0.41
CYP2C18 P33260 1/20 0.41
CYP2C19 P33261 1/20 0.41
KCNH2 Q12809 1/20 0.41
ITGB3 P05106 1/20 0.40
ITGA2B P08514 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21962778 0.90 MLYCD (0.48) MLYCDHDAC2HDAC1HDAC3HDAC4
SCHEMBL21962816 0.89 MLYCD (0.48) MLYCDHDAC2HDAC1HDAC3HDAC4
SCHEMBL21962569 0.88 MLYCD (0.49) MLYCDHDAC2HDAC1HDAC3HDAC4
SCHEMBL21962622 0.87 RAF1 (0.47) MLYCDHDAC2HDAC1HDAC3HDAC4
SCHEMBL21962573 0.86 MLYCD (0.46) MLYCDHDAC2HDAC1HDAC3HDAC4
SCHEMBL22019123 0.86 HDAC3 (0.54) MLYCDHDAC2HDAC1HDAC3HDAC4
SCHEMBL21962656 0.85 HDAC3 (0.61) MLYCDHDAC2HDAC1HDAC3HDAC4
SCHEMBL21962658 0.85 MLYCD (0.40) MLYCDHDAC2HDAC1HDAC3HDAC4
SCHEMBL21962836 0.84 RAF1 (0.44) MLYCDHDAC2HDAC1HDAC3HDAC4
SCHEMBL21962795 0.83 MLYCD (0.42) MLYCDHDAC2HDAC1HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020102575-A1 HETEROCYCLIC AMINOTHIAZOLES AND USES THEREOF INCEPTION IBD, INC. (US) 2020-05-22 WO claimed
WO-2020102575-A1 HETEROCYCLIC AMINOTHIAZOLES AND USES THEREOF INCEPTION IBD, INC. (US) 2020-05-22 WO disclosed
WO-2020102575-A1 HETEROCYCLIC AMINOTHIAZOLES AND USES THEREOF INCEPTION IBD, INC. (US) 2020-05-22 WO disclosed