Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 2/20 | 0.42 |
| ▸ | TLR2 | O60603 | 5/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.40 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21963478 | 1.00 | MDM2 (0.42) | MDM2TLR2SIRT2SIRT1TLR1 | |
| SCHEMBL31298675 | 0.93 | ALB (0.47) | MDM2TLR2ALB | |
| SCHEMBL20530037 | 0.93 | ALB (0.47) | MDM2TLR2ALB | |
| SCHEMBL31298693 | 0.91 | ALB (0.48) | TLR2TLR1ALB | |
| SCHEMBL22022022 | 0.90 | TLR2 (0.41) | TLR2SIRT2SIRT1TLR1SIRT3 | |
| SCHEMBL22021730 | 0.90 | TLR2 (0.41) | MDM2TLR2SIRT2SIRT1TLR1 | |
| SCHEMBL30895538 | 0.89 | TLR2 (0.49) | MDM2TLR2TLR1 | |
| SCHEMBL29521884 | 0.88 | TLR2 (0.41) | MDM2TLR2SIRT2TLR1CA1 | |
| SCHEMBL30895452 | 0.88 | TLR2 (0.48) | MDM2TLR2TLR1 | |
| SCHEMBL30895592 | 0.86 | TLR2 (0.51) | MDM2TLR2TLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880253-A1 | THIOAMIDE-CONTAINING COMPOSITIONS AND METHODS OF USE THEREOF | Noria Therapeutics, Inc. (US) | 2021-09-22 | — | — | EP | disclosed |
| WO-2020102348-A1 | THIOAMIDE-CONTAINING COMPOSITIONS AND METHODS OF USE THEREOF | DIMAGNO STEPHEN (US) | 2020-05-22 | — | — | WO | disclosed |