Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20898289 | 0.88 | ACACB (0.36) | KMT2AMEN1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL22555742 | 0.87 | KMT2A (0.36) | TP53TSHRUSP2KMT2AMEN1 | |
| SCHEMBL22567674 | 0.84 | ACACB (0.36) | TP53TSHRUSP2KMT2AMEN1 | |
| SCHEMBL22555824 | 0.84 | ALDH1A1 (0.37) | TP53TSHRUSP2KMT2AMEN1 | |
| SCHEMBL20907250 | 0.84 | ACACB (0.36) | TP53TSHRUSP2KMT2AMEN1 | |
| SCHEMBL22555743 | 0.84 | KMT2A (0.39) | TP53TSHRUSP2KMT2AMEN1 | |
| SCHEMBL22567379 | 0.84 | ACACB (0.36) | TP53TSHRUSP2KMT2AMEN1 | |
| SCHEMBL20898268 | 0.83 | TDP1 (0.31) | GAAMAPTKDM4ELMNA | |
| SCHEMBL22555795 | 0.83 | ALDH1A1 (0.35) | TSHRUSP2KMT2AMEN1ALDH1A1 | |
| SCHEMBL20898267 | 0.82 | POLB (0.33) | MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880664-A1 | LOX INHIBITORS | The Institute of Cancer Research: Royal Cancer Hospital (GB) | 2021-09-22 | — | — | EP | disclosed |
| WO-2020099886-A1 | LOX INHIBITORS | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2020-05-22 | — | — | WO | disclosed |