Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10237604 | 0.85 | OPRM1 (0.50) | OPRM1KDM4EKMT2ASMYD3 | |
| SCHEMBL14964737 | 0.80 | KDM4E (0.39) | OPRM1KDM4EKMT2ANPSR1CYP4F2 | |
| SCHEMBL25362997 | 0.79 | KDM4E (0.44) | OPRM1KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL14964736 | 0.79 | KDM4E (0.38) | OPRM1KDM4EKMT2ANPSR1CYP4F2 | |
| SCHEMBL31509519 | 0.78 | OPRM1 (0.34) | OPRM1KDM4EKMT2A | |
| SCHEMBL27914276 | 0.78 | KDM4E (0.35) | OPRM1KDM4EKMT2ANPSR1 | |
| Hydrochloric Acid SCHEMBL28087372 | 0.76 | KDM4E (0.34) | OPRM1KDM4EKMT2ANPSR1 | |
| SCHEMBL31382252 | 0.76 | OPRM1 (0.37) | OPRM1KDM4EKMT2ANPSR1CYP4F2 | |
| SCHEMBL12373913 | 0.73 | NPSR1 (0.34) | OPRM1KDM4EKMT2ANPSR1 | |
| SCHEMBL16310454 | 0.73 | OPRM1 (0.42) | OPRM1KDM4EKMT2ANPSR1CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880308-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | The University Of Sheffield (GB) | 2021-09-22 | — | — | EP | disclosed |
| WO-2020099885-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | THE UNIVERSITY OF SHEFFIELD (GB) | 2020-05-22 | — | — | WO | disclosed |