Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 9/20 | 0.40 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | STAT1 | P42224 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.38 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17850058 | 0.80 | CHEK1 (0.49) | CHEK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL22758 | 0.79 | DGAT1 (0.38) | CHEK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL15031603 | 0.79 | DGAT1 (0.38) | CHEK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL15007079 | 0.79 | DGAT1 (0.38) | CHEK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL22763 | 0.79 | DGAT1 (0.42) | CHEK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL18721 | 0.78 | CHEK1 (0.47) | CHEK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL15007234 | 0.77 | MTOR (0.42) | CHEK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL21487 | 0.77 | MTOR (0.42) | CHEK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL20915 | 0.77 | MTOR (0.42) | CHEK1CCNA2CDK2CCNA1MAPT | |
| SCHEMBL30996 | 0.77 | DGAT1 (0.37) | CHEK1CCNA2CDK2CCNA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027236-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |