Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21961616 | 1.00 | CYP3A4 (0.78) | CYP3A4CYP2C19HSD11B1MEN1KMT2A | |
| SCHEMBL21961586 | 0.98 | CYP3A4 (0.80) | CYP3A4CYP2C19HSD11B1MEN1KMT2A | |
| SCHEMBL21965003 | 0.95 | CYP3A4 (0.75) | CYP3A4CYP2C19HSD11B1MEN1KMT2A | |
| SCHEMBL21964279 | 0.87 | CYP3A4 (0.64) | CYP3A4CYP2C19HSD11B1MEN1KMT2A | |
| SCHEMBL21965004 | 0.87 | CYP3A4 (0.81) | CYP3A4CYP2C19HSD11B1MEN1KMT2A | |
| SCHEMBL21965008 | 0.84 | CYP3A4 (0.71) | CYP3A4CYP2C19HSD11B1MEN1KMT2A | |
| SCHEMBL18390063 | 0.82 | CYP3A4 (0.65) | CYP3A4CYP2C19HSD11B1MEN1KMT2A | |
| SCHEMBL21964333 | 0.81 | HSD11B1 (0.61) | CYP3A4CYP2C19HSD11B1MEN1KMT2A | |
| SCHEMBL21733049 | 0.81 | CYP3A4 (0.64) | CYP3A4CYP2C19HSD11B1MEN1KMT2A | |
| SCHEMBL18390072 | 0.81 | CYP3A4 (0.64) | CYP3A4CYP2C19HSD11B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643703-A1 | EP300/CREBBP INHIBITOR | Daiichi Sankyo Co., Ltd. (JP) | 2020-04-29 | — | — | EP | disclosed |