Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16800423 | 0.87 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2POLBMGLL | |
| SCHEMBL16797992 | 0.79 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2POLBMGLL | |
| SCHEMBL21960377 | 0.77 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2POLBMGLL | |
| SCHEMBL10489745 | 0.71 | NPC1 (0.56) | NPC1RAB9APOLBMGLLATM | |
| SCHEMBL3087030 | 0.71 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2POLBCTSK | |
| SCHEMBL21960979 | 0.70 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2POLBMGLL | |
| SCHEMBL5853278 | 0.69 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2POLBMGLL | |
| SCHEMBL3295253 | 0.69 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2POLBMGLL | |
| SCHEMBL8646687 | 0.68 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2POLBMGLL | |
| SCHEMBL23835788 | 0.68 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2POLBMAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |