Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 4/20 | 0.53 |
| ▸ | CDK4 | P11802 | 12/20 | 0.38 |
| ▸ | CCND1 | P24385 | 12/20 | 0.38 |
| ▸ | CCND2 | P30279 | 9/20 | 0.38 |
| ▸ | CCND3 | P30281 | 9/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.37 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.37 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.37 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1046099 | 0.87 | MAPKAPK5 (0.58) | MAPKAPK5CDK4CCND1CCND2CCND3 | |
| SCHEMBL1048035 | 0.85 | MAPKAPK5 (0.57) | MAPKAPK5CDK4CCND1CCND2CCND3 | |
| SCHEMBL1047106 | 0.84 | MAPKAPK5 (0.60) | MAPKAPK5CDK4CCND1CDK6HRH3 | |
| SCHEMBL2200727 | 0.81 | ACVR1 (0.44) | MAPKAPK5CDK4CCND1CCND2CCND3 | |
| SCHEMBL2197955 | 0.77 | ACVR1 (0.45) | MAPKAPK5HRH3FGFR1FGFR4ALDH1A1 | |
| SCHEMBL10134462 | 0.76 | MAPKAPK5 (0.58) | MAPKAPK5CDK4CCND1CCND2CCND3 | |
| SCHEMBL1043477 | 0.74 | MAPKAPK5 (0.76) | MAPKAPK5 | |
| SCHEMBL1044262 | 0.73 | CDK4 (0.41) | CDK4CCND1CCND2CCND3CDK6 | |
| SCHEMBL1047036 | 0.73 | MAPKAPK5 (0.62) | MAPKAPK5CDK4CCND1CCND2CCND3 | |
| SCHEMBL10134496 | 0.73 | MAPKAPK5 (0.57) | MAPKAPK5CDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977352-B2 | Triazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases | GALAPAGOS NV (BE) | 2011-07-12 | — | — | US | disclosed |