Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 3/20 | 0.36 |
| ▸ | CCND1 | P24385 | 3/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.36 |
| ▸ | CCND2 | P30279 | 2/20 | 0.35 |
| ▸ | CCND3 | P30281 | 2/20 | 0.35 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197955 | 0.97 | ACVR1 (0.45) | ACVR1FGFR1HRH3KCNH2FGFR4 | |
| SCHEMBL1044786 | 0.88 | ACVR1 (0.42) | ACVR1FGFR1HRH3KCNH2FGFR2 | |
| SCHEMBL1046311 | 0.85 | ACVR1 (0.42) | ACVR1FGFR1HRH3KCNH2FGFR2 | |
| SCHEMBL1046069 | 0.84 | ACVR1 (0.44) | ACVR1FGFR1HRH3KCNH2PDE1B | |
| SCHEMBL2196472 | 0.81 | MAPKAPK5 (0.53) | FGFR1HRH3FGFR2FGFR4FGFR3 | |
| SCHEMBL12618630 | 0.77 | FGFR1 (0.42) | ACVR1FGFR1HRH3KCNH2FGFR2 | |
| SCHEMBL1048208 | 0.75 | MAPKAPK5 (0.49) | MAPKAPK2KDM1AMAPKAPK5 | |
| SCHEMBL12618649 | 0.74 | ACVR1 (0.41) | ACVR1FGFR1HRH3KCNH2FGFR2 | |
| SCHEMBL12618627 | 0.73 | ACVR1 (0.42) | ACVR1FGFR1HRH3KCNH2MAPKAPK2 | |
| SCHEMBL1047450 | 0.73 | FGFR1 (0.46) | FGFR1FGFR2FGFR4FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977352-B2 | Triazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases | GALAPAGOS NV (BE) | 2011-07-12 | — | — | US | disclosed |