Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 12/20 | 0.45 |
| ▸ | KIT | P10721 | 11/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.36 |
| ▸ | RIOK2 | Q9BVS4 | 2/20 | 0.36 |
| ▸ | TLK1 | Q9UKI8 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | STK25 | O00506 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12225668 | 1.00 | KDR (0.45) | KDRPDGFRBKITLRRK2FLT3 | |
| SCHEMBL2196880 | 1.00 | KDR (0.45) | KDRPDGFRBKITLRRK2FLT3 | |
| SCHEMBL12225681 | 0.95 | PDGFRB (0.45) | KDRPDGFRBKITLRRK2FLT3 | |
| SCHEMBL2199737 | 0.95 | PDGFRB (0.45) | KDRPDGFRBKITLRRK2FLT3 | |
| SCHEMBL2199742 | 0.95 | PDGFRB (0.45) | KDRPDGFRBKITLRRK2FLT3 | |
| SCHEMBL2535738 | 0.92 | FLT3 (0.41) | KDRPDGFRBKITLRRK2FLT3 | |
| SCHEMBL2199395 | 0.92 | FLT3 (0.41) | KDRPDGFRBKITLRRK2FLT3 | |
| SCHEMBL12225676 | 0.92 | FLT3 (0.41) | KDRPDGFRBKITLRRK2FLT3 | |
| SCHEMBL12225650 | 0.91 | LRRK2 (0.45) | KDRPDGFRBKITLRRK2FLT3 | |
| SCHEMBL2199801 | 0.91 | LRRK2 (0.45) | KDRPDGFRBKITLRRK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977351-B2 | Heteroaryl dihydroindolones as kinase inhibitors | ALLERGAN, INC. (US) | 2011-07-12 | — | — | US | claimed |
| US-20080045526-A1 | HETEROARYL DIHYDROINDOLONES AS KINASE INHIBITORS | ALLERGAN, INC. | 2008-02-21 | — | — | US | claimed |
| US-8455535-B2 | Heteroaryl dihydroindolones as kinase inhibitors | ALLERGAN, INC. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20110257238-A1 | Heteroaryl Dihydroindolones as Kinase Inhibitors | ALLERGAN, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| US-7977351-B2 | Heteroaryl dihydroindolones as kinase inhibitors | ALLERGAN, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20080045526-A1 | HETEROARYL DIHYDROINDOLONES AS KINASE INHIBITORS | ALLERGAN, INC. | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257238-A1 | Heteroaryl Dihydroindolones as Kinase Inhibitors | REN, JAK2, ABL1 | KDR 25/4885PDGFRB 11/4885KIT 367/4885 |
| US-20080045526-A1 | HETEROARYL DIHYDROINDOLONES AS KINASE INHIBITORS | REN, JAK2, ABL1 | KDR 25/4885PDGFRB 11/4885KIT 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.