Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | LONP1 | P36776 | 7/20 | 0.52 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.52 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.52 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.52 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.52 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.52 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.52 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.52 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.52 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.52 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.52 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.52 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.52 |
| ▸ | PSMB3 | P49720 | 2/20 | 0.52 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.52 |
| ▸ | PSMA6 | P60900 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30786951 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2HTTLONP1PSMB11PSMA7 | |
| SCHEMBL21968828 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2HTTLONP1PSMB11PSMA7 | |
| SCHEMBL21968901 | 0.85 | LONP1 (0.60) | SMN1; SMN2HTTLONP1PSMB11PSMA7 | |
| SCHEMBL5837260 | 0.85 | LONP1 (0.60) | SMN1; SMN2HTTLONP1PSMB11PSMA7 | |
| SCHEMBL10255381 | 0.84 | LONP1 (0.53) | SMN1; SMN2HTTLONP1PSMB11PSMA7 | |
| SCHEMBL30017450 | 0.81 | LONP1 (0.46) | SMN1; SMN2HTTLONP1PSMB11PSMA7 | |
| SCHEMBL30786953 | 0.81 | LONP1 (0.46) | SMN1; SMN2HTTLONP1PSMB11PSMA7 | |
| SCHEMBL30018942 | 0.81 | LONP1 (0.46) | SMN1; SMN2HTTLONP1PSMB11PSMA7 | |
| SCHEMBL21274317 | 0.81 | KDM4E (0.50) | SMN1; SMN2HTTPSMB5AKR1B1KDM4E | |
| SCHEMBL8742393 | 0.81 | KDM4E (0.50) | SMN1; SMN2HTTPSMB5AKR1B1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159471-A1 | PYRAZINOIC ACID CONJUGATES AND HYBRID CONJUGATES | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (US) | 2023-05-25 | — | — | US | disclosed |
| US-11584725-B2 | Pyrazinoic acid conjugates and hybrid conjugates | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (US) | 2023-02-21 | — | — | US | disclosed |
| US-20200140397-A1 | PYRAZINOIC ACID CONJUGATES AND HYBRID CONJUGATES | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. | 2020-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584725-B2 | Pyrazinoic acid conjugates and hybrid conjugates | QPCT, RARA, PNKP | SMN1; SMN2 4368/4885HTT 3167/4885LONP1 3776/4885 |
| US-20200140397-A1 | PYRAZINOIC ACID CONJUGATES AND HYBRID CONJUGATES | QPCT, RARA, PNKP | SMN1; SMN2 4368/4885HTT 3167/4885LONP1 3776/4885 |
| US-20230159471-A1 | PYRAZINOIC ACID CONJUGATES AND HYBRID CONJUGATES | QPCT, RARA, PNKP | SMN1; SMN2 4368/4885HTT 3167/4885LONP1 3776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.