Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10900264 | 0.87 | HRH3 (0.49) | HRH3KCNH2PDE3APDE3BITGB3 | |
| SCHEMBL10753732 | 0.83 | HRH3 (0.46) | HRH3KCNH2PDE3APDE3BMAPT | |
| SCHEMBL10341508 | 0.81 | PDE3B (0.53) | HRH3KCNH2PDE3APDE3BMAPT | |
| SCHEMBL10341540 | 0.81 | HRH3 (0.50) | HRH3KCNH2PDE3APDE3BITGB3 | |
| SCHEMBL10740298 | 0.76 | PDE3A (0.50) | HRH3KCNH2PDE3APDE3BGALR3 | |
| SCHEMBL9602068 | 0.76 | HRH3 (0.57) | HRH3KCNH2PDE3APDE3BGALR3 | |
| SCHEMBL8305150 | 0.76 | HRH3 (0.54) | HRH3KCNH2PDE3APDE3BGPR119 | |
| SCHEMBL10753296 | 0.76 | HRH3 (0.54) | HRH3KCNH2PDE3APDE3B | |
| Hydrochloric Acid SCHEMBL11092318 | 0.76 | PDE3B (0.49) | HRH3KCNH2PDE3APDE3BGALR3 | |
| Hydrochloric Acid SCHEMBL7314082 | 0.75 | HRH3 (0.56) | HRH3KCNH2PDE3APDE3BGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970145-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | BROAD INST INC (US) | 2020-05-06 | — | — | EP | disclosed |