Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 15/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305150 | 0.84 | HRH3 (0.54) | HRH3KCNH2PDE3APDE3B | |
| SCHEMBL9602068 | 0.84 | HRH3 (0.57) | HRH3KCNH2PDE3APDE3B | |
| Hydrochloric Acid SCHEMBL7314082 | 0.83 | HRH3 (0.56) | HRH3KCNH2PDE3APDE3BPDE4B | |
| SCHEMBL10341530 | 0.82 | HRH3 (0.53) | HRH3KCNH2PDE3APDE3B | |
| SCHEMBL10341540 | 0.81 | HRH3 (0.50) | HRH3KCNH2PDE3APDE3BPDE4B | |
| SCHEMBL10341521 | 0.81 | HRH3 (0.62) | HRH3KCNH2PDE3APDE3BPDE4B | |
| SCHEMBL10341574 | 0.80 | PDE3A (0.50) | HRH3KCNH2PDE3APDE3BPDE4B | |
| SCHEMBL7312758 | 0.78 | PDE3A (0.59) | HRH3KCNH2PDE3APDE3BPDE4B | |
| SCHEMBL10754393 | 0.77 | HRH3 (0.48) | HRH3KCNH2PDE3APDE3BPDE4B | |
| SCHEMBL10341508 | 0.77 | PDE3B (0.53) | HRH3KCNH2PDE3APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4692447-A | HYPOTENSIVE, VASODILATOR, ANTITHROMBOTIC, ANTIAGGREGANT, CYTOPROTECTIVE | BOEHRINGER BIOCHEMIA ROBIN, S.P.A. (IT) | 1987-09-08 | — | — | US | disclosed |