Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | NMT1 | P30419 | 6/20 | 0.43 |
| ▸ | NMT2 | O60551 | 5/20 | 0.43 |
| ▸ | TLR2 | O60603 | 2/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21944205 | 0.90 | SIRT6 (0.47) | SIRT6SIRT1NMT1NMT2TLR2 | |
| SCHEMBL23685586 | 0.84 | SIRT6 (0.53) | SIRT6SIRT1NMT1NMT2TLR2 | |
| SCHEMBL18806403 | 0.83 | SIRT6 (0.52) | SIRT6SIRT1NMT1NMT2TLR2 | |
| SCHEMBL15393668 | 0.80 | FOLH1 (0.43) | SIRT6SIRT1FOLH1SIRT5CPB2 | |
| SCHEMBL17087723 | 0.80 | SIRT6 (0.48) | SIRT6SIRT1NMT1NMT2TLR2 | |
| SCHEMBL14942513 | 0.80 | SIRT6 (0.48) | SIRT6SIRT1NMT1NMT2TLR2 | |
| SCHEMBL22519362 | 0.80 | TLR2 (0.46) | SIRT6SIRT1NMT1NMT2TLR2 | |
| SCHEMBL24860089 | 0.80 | FOLH1 (0.55) | SIRT6SIRT1NMT1NMT2FOLH1 | |
| SCHEMBL14426180 | 0.80 | TLR2 (0.46) | SIRT6SIRT1NMT1NMT2TLR2 | |
| SCHEMBL15905754 | 0.80 | SIRT6 (0.48) | SIRT6SIRT1NMT1NMT2TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928501-B1 | CARRIER-LINKED PROSTANOID PRODRUGS | ASCENDIS PHARMA AS (DK) | 2020-05-06 | — | — | EP | disclosed |