Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | NCF1 | P14598 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 6/20 | 0.46 |
| ▸ | MIF | P14174 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12403523 | 1.00 | MAPT (0.65) | MAPTNCF1KDM4EMAPK1TDP1 | |
| SCHEMBL483977 | 0.85 | APP (0.65) | MAPTNCF1APP | |
| SCHEMBL12402791 | 0.80 | MAPT (0.57) | MAPTNCF1KDM4ENPC1RAB9A | |
| SCHEMBL483920 | 0.80 | MAPT (0.56) | MAPTNCF1KDM4ENPC1RAB9A | |
| SCHEMBL2163057 | 0.80 | MAPT (0.53) | MAPTNCF1APPMIF | |
| SCHEMBL483802 | 0.79 | MAPT (0.55) | MAPTNCF1KDM4ENPC1RAB9A | |
| SCHEMBL15949844 | 0.79 | MAPT (1.00) | MAPTNCF1KDM4ENPC1RAB9A | |
| SCHEMBL29409748 | 0.79 | MAPT (1.00) | MAPTNCF1KDM4ENPC1RAB9A | |
| SCHEMBL483456 | 0.79 | NCF1 (0.62) | MAPTNCF1KDM4EMAPK1TDP1 | |
| SCHEMBL28180362 | 0.78 | MAPT (0.55) | MAPTNCF1KDM4EMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411057-B1 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | LILLY CO ELI (US) | 2020-05-06 | — | — | EP | disclosed |