Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | BCR | P11274 | 2/20 | 0.45 |
| ▸ | C5 | P01031 | 2/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.43 |
| ▸ | CHUK | O15111 | 2/20 | 0.43 |
| ▸ | IKBKG | Q9Y6K9 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12423379 | 1.00 | ABL1 (0.45) | ABL1BCRC5AKT3IKBKB | |
| SCHEMBL12423703 | 0.92 | C5 (0.46) | C5AKT3SYKCAMK2DROCK1 | |
| SCHEMBL13052286 | 0.92 | C5 (0.46) | C5AKT3SYKCAMK2DROCK1 | |
| SCHEMBL3098965 | 0.86 | ABL1 (0.48) | ABL1BCRAKT3IKBKBCHUK | |
| SCHEMBL12423321 | 0.86 | AURKB (0.51) | AKT3IKBKBCHUKIKBKGCAMK2D | |
| SCHEMBL2198512 | 0.86 | AURKB (0.51) | AKT3IKBKBCHUKIKBKGCAMK2D | |
| SCHEMBL4929463 | 0.81 | AURKB (0.52) | AKT3IKBKBCHUKIKBKGCAMK2D | |
| SCHEMBL4929513 | 0.81 | AURKB (0.52) | AKT3IKBKBCHUKIKBKGCAMK2D | |
| SCHEMBL13181306 | 0.80 | CAMK2D (0.47) | AKT3IKBKBCHUKIKBKGCAMK2D | |
| SCHEMBL13154237 | 0.80 | AKT3 (0.49) | AKT3IKBKBCHUKIKBKGCAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977481-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-7977481-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20100305128-A1 | Pyrimidinyl-Thiophene Kinase Modulators | ARNOLD WILLIAM D | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305128-A1 | Pyrimidinyl-Thiophene Kinase Modulators | MAP3K20, MAP3K6, MAP4K2 | ABL1 45/4885BCR 981/4885C5 4855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.