Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18229661 | 0.82 | HDAC6 (0.73) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL18229533 | 0.81 | HDAC6 (0.75) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL18229605 | 0.81 | HDAC6 (0.71) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL21976290 | 0.80 | HDAC6 (0.72) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL18229591 | 0.79 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL18229658 | 0.77 | HDAC6 (0.64) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL21976472 | 0.77 | HDAC6 (0.70) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL18229582 | 0.77 | HDAC6 (0.66) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL21976298 | 0.76 | HDAC6 (0.61) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL18229490 | 0.75 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294715-B1 | BENZIMIDAZOLE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2020-05-06 | — | — | EP | disclosed |