Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 8/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 4/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12490508 | 0.84 | BRD4 (0.40) | GCKPTGS2PTGS1BRD4MAPT | |
| SCHEMBL12490119 | 0.80 | GCK (0.46) | GCKPTGS2PTGS1 | |
| SCHEMBL2195791 | 0.76 | GCK (0.44) | GCK | |
| SCHEMBL2196134 | 0.74 | GCK (0.47) | GCK | |
| SCHEMBL12489676 | 0.72 | GPR6 (0.39) | GCKPTGS2PTGS1BRD4GPR6 | |
| SCHEMBL1960655 | 0.70 | GCK (0.52) | GCK | |
| SCHEMBL1959200 | 0.69 | GCK (0.51) | GCK | |
| SCHEMBL2179681 | 0.69 | GCK (0.48) | GCKBRD4 | |
| SCHEMBL1962013 | 0.67 | GCK (0.75) | GCK | |
| SCHEMBL2195649 | 0.67 | GCK (0.45) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011080755-A1 | FUSED NITROGEN HETEROCYCLIC COMPOUNDS, PROCESS OF PREPARATION AND USES THEREOF | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |