Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.37 |
| ▸ | IGF1R | P08069 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.32 |
| ▸ | MERTK | Q12866 | 2/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197811 | 0.85 | IGF1R (0.38) | PLK1IGF1RCDK2TYRO3IDH1 | |
| SCHEMBL2197869 | 0.83 | PLK1 (0.35) | PLK1IGF1RCDK2TYRO3MERTK | |
| SCHEMBL2199550 | 0.83 | PLK1 (0.35) | PLK1IGF1RCDK2TYRO3MERTK | |
| SCHEMBL2198011 | 0.83 | PLK1 (0.35) | PLK1IGF1RCDK2TYRO3MERTK | |
| SCHEMBL2197910 | 0.82 | PLK1 (0.38) | PLK1IGF1RCDK2TYRO3MERTK | |
| SCHEMBL2226580 | 0.80 | PLK1 (0.38) | PLK1IGF1RCDK2TYRO3MERTK | |
| SCHEMBL2196904 | 0.80 | IGF1R (0.36) | PLK1IGF1RCDK2IDH1 | |
| SCHEMBL2227194 | 0.80 | TYRO3 (0.39) | PLK1IGF1RCDK2TYRO3MERTK | |
| SCHEMBL2196677 | 0.79 | PLK1 (0.39) | PLK1IGF1RCDK2TYRO3MERTK | |
| SCHEMBL19951509 | 0.79 | PLK1 (0.39) | PLK1IGF1RCDK2TYRO3MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977336-B2 | Aminopyrimidine derivatives as PLK1 inhibitors | BANYU PHARMACEUTICAL CO. LTD (JP) | 2011-07-12 | — | — | US | disclosed |