Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.34 |
| ▸ | MERTK | Q12866 | 3/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197869 | 1.00 | PLK1 (0.35) | PLK1TYRO3MERTKIGF1RCDK2 | |
| SCHEMBL2197909 | 0.83 | PLK1 (0.37) | PLK1TYRO3MERTKIGF1RCDK2 | |
| SCHEMBL2197872 | 0.81 | PLK1 (0.38) | PLK1TYRO3MERTKIGF1RCDK2 | |
| SCHEMBL5065506 | 0.81 | PLK1 (0.38) | PLK1TYRO3MERTKIGF1RCDK2 | |
| SCHEMBL2196904 | 0.81 | IGF1R (0.36) | PLK1IGF1RCDK2CDK1IDH1 | |
| SCHEMBL3558549 | 0.81 | PLK1 (0.41) | PLK1TYRO3MERTKIGF1RCDK2 | |
| SCHEMBL2200780 | 0.79 | PLK1 (0.36) | PLK1TYRO3MERTKIGF1RCDK2 | |
| SCHEMBL2202182 | 0.78 | PLK1 (0.36) | PLK1TYRO3MERTKIGF1RCDK2 | |
| SCHEMBL2197365 | 0.78 | PLK1 (0.36) | PLK1TYRO3MERTKIGF1RCDK2 | |
| SCHEMBL2198778 | 0.78 | PLK1 (0.36) | PLK1TYRO3MERTKIGF1RCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977336-B2 | Aminopyrimidine derivatives as PLK1 inhibitors | BANYU PHARMACEUTICAL CO. LTD (JP) | 2011-07-12 | — | — | US | disclosed |