Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL531389 | 0.78 | MEN1 (0.57) | TSHRALDH1A1RIPK1MEN1KMT2A | |
| SCHEMBL1640061 | 0.77 | TSHR (0.58) | TSHRALDH1A1AOC3RIPK1MEN1 | |
| SCHEMBL340999 | 0.74 | CARM1 (0.46) | TSHRALDH1A1AOC3RIPK1MEN1 | |
| SCHEMBL11249019 | 0.74 | TSHR (0.54) | TSHRALDH1A1AOC3RIPK1MEN1 | |
| SCHEMBL20844585 | 0.74 | AOC3 (0.56) | TSHRALDH1A1AOC3RIPK1NPC1 | |
| SCHEMBL27258851 | 0.74 | TSHR (0.54) | TSHRALDH1A1AOC3RIPK1NPC1 | |
| Ethyne SCHEMBL1921084 | 0.72 | TSHR (0.52) | TSHRALDH1A1AOC3MEN1KMT2A | |
| SCHEMBL19954207 | 0.72 | TSHR (0.52) | TSHRALDH1A1AOC3RIPK1NPC1 | |
| SCHEMBL21612148 | 0.71 | MEN1 (0.38) | TSHRALDH1A1MEN1KMT2AHTT | |
| SCHEMBL967209 | 0.71 | TSHR (0.56) | TSHRALDH1A1AOC3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101573361-B | Aminopyrimidine derivatives as PLK1 inhibitors | MSD KK | 2012-05-30 | — | — | CN | disclosed |
| US-7977336-B2 | Aminopyrimidine derivatives as PLK1 inhibitors | BANYU PHARMACEUTICAL CO. LTD (JP) | 2011-07-12 | — | — | US | disclosed |
| EP-2116543-A1 | NOVEL AMINOPYRIMIDINE DERIVATIVE AS PLK1 INHIBITOR | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-11-11 | — | — | EP | disclosed |
| CN-101573361-A | Novel aminopyrimidine derivative as plk1 inhibitor | BANYU PHARMA CO LTD (JP) | 2009-11-04 | — | — | CN | disclosed |
| US-20080305081-A1 | Novel aminopyrimidine derivatives as PLK1 inhibitors | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080305081-A1 | Novel aminopyrimidine derivatives as PLK1 inhibitors | PLK1, AURKA, CDK1 | TSHR 3070/4885ALDH1A1 3451/4885AOC3 4157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.