⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213524 | 1.00 | — | — | |
| SCHEMBL4078483 | 1.00 | — | — | |
| SCHEMBL209161 | 1.00 | — | — | |
| SCHEMBL2193904 | 1.00 | — | — | |
| SCHEMBL4563322 | 0.91 | — | — | |
| SCHEMBL4563324 | 0.91 | — | — | |
| SCHEMBL3134477 | 0.89 | — | — | |
| SCHEMBL3134430 | 0.89 | — | — | |
| SCHEMBL1408601 | 0.88 | — | — | |
| SCHEMBL4087414 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501805-B2 | Substituted alpha-L-bicyclic nucleosides | ISIS PHARMACEUTICALS, INC. (US) | 2013-08-06 | — | — | US | disclosed |
| EP-2356129-B1 | SUBSTITUTED ALPHA-L-BICYCLIC NUCLEOSIDES | ISIS PHARMACEUTICALS INC (US) | 2013-04-03 | — | — | EP | disclosed |
| US-20110166205-A1 | SUBSTITUTED ALPHA-L-BICYCLIC NUCLEOSIDES | IONIS PHARMACEUTICALS, INC. | 2011-07-07 | — | — | US | disclosed |