Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | IDE | P14735 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 2/20 | 0.51 |
| ▸ | PLCD1 | P51178 | 1/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.50 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16452817 | 0.89 | CAPN1 (0.69) | CAPN1TDP1CA12CA1CA2 | |
| SCHEMBL22921014 | 0.86 | TDP1 (0.74) | CAPN1TDP1CA12CA1CA2 | |
| SCHEMBL21140191 | 0.86 | TDP1 (0.70) | CAPN1TDP1CA12CA1CA2 | |
| SCHEMBL24067575 | 0.85 | TDP1 (0.76) | CAPN1TDP1CA12CA1CA2 | |
| SCHEMBL6195019 | 0.85 | TDP1 (0.70) | CAPN1TDP1CA12CA1CA2 | |
| SCHEMBL24443427 | 0.85 | TDP1 (0.73) | CAPN1TDP1CA12CA1CA2 | |
| SCHEMBL21140233 | 0.85 | TDP1 (0.69) | CAPN1TDP1CA12CA1CA2 | |
| SCHEMBL14570855 | 0.85 | TDP1 (0.74) | CAPN1TDP1CA12CA1CA2 | |
| SCHEMBL14523052 | 0.84 | TDP1 (0.70) | CAPN1TDP1CA12CA1CA2 | |
| SCHEMBL13609688 | 0.83 | TDP1 (0.73) | CAPN1TDP1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647709-B2 | Cysteine protease inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647709-B2 | Cysteine protease inhibitors and uses thereof | CAPNS1, CAPN9, CAPN1 | CAPN1 3/4885TDP1 1365/4885CA12 759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.