Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 20/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 20/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 17/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17975722 | 0.83 | GRIN1 (0.61) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16645680 | 0.83 | GRIN1 (0.61) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL17975723 | 0.77 | GRIN2A (0.69) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL17975721 | 0.77 | GRIN2A (0.80) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16645677 | 0.77 | GRIN2A (0.69) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16645845 | 0.77 | GRIN2A (0.80) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL20403421 | 0.75 | GRIN2A (0.59) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16637422 | 0.75 | GRIN2A (0.74) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL20403489 | 0.74 | GRIN2A (0.61) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16636628 | 0.74 | GRIN2A (0.70) | GRIN1GRIN2AGRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647731-B2 | Thiazolopyrimidinones and methods of use thereof | GENENTECH, INC. (US) | 2020-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647731-B2 | Thiazolopyrimidinones and methods of use thereof | TPMT, THPO, CYP11B2 | GRIN1 2250/4885GRIN2A 2506/4885GRIA2 2761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.