Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 8/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16867795 | 0.70 | PDE2A (1.00) | PDE2A | |
| SCHEMBL18255573 | 0.66 | PDE2A (1.00) | PDE2A | |
| SCHEMBL16868047 | 0.64 | PDE2A (1.00) | PDE2A | |
| SCHEMBL21985486 | 0.62 | LDHB (0.40) | PDE2A | |
| SCHEMBL21985610 | 0.59 | PDE2A (0.52) | PDE2A | |
| SCHEMBL16868043 | 0.56 | PDE2A (0.77) | PDE2A | |
| SCHEMBL12946278 | 0.54 | PDE2A (0.67) | PDE2A | |
| SCHEMBL13525247 | 0.54 | ANO1 (0.36) | PDE2A | |
| SCHEMBL17517022 | 0.52 | PDE2A (0.44) | PDE2A | |
| SCHEMBL22589735 | 0.52 | KDM4E (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3087060-B1 | PYRIMIDONE CARBOXAMIDE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2020-05-13 | — | — | EP | disclosed |