Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 18/20 | 0.81 |
| ▸ | F11 | P03951 | 9/20 | 0.65 |
| ▸ | F2 | P00734 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21145550 | 0.90 | KLKB1 (0.79) | KLKB1F11F2 | |
| SCHEMBL17785422 | 0.90 | KLKB1 (1.00) | KLKB1F11F2 | |
| SCHEMBL31339413 | 0.90 | KLKB1 (1.00) | KLKB1F11F2 | |
| SCHEMBL21145604 | 0.85 | KLKB1 (0.81) | KLKB1F11F2 | |
| SCHEMBL21145557 | 0.85 | F11 (0.80) | KLKB1F11F2 | |
| SCHEMBL21145576 | 0.81 | KLKB1 (0.86) | KLKB1F11F2 | |
| SCHEMBL21145620 | 0.81 | KLKB1 (1.00) | KLKB1F11F2 | |
| SCHEMBL21145573 | 0.79 | KLKB1 (1.00) | KLKB1F11F2 | |
| SCHEMBL19668198 | 0.78 | KLKB1 (1.00) | KLKB1F11F2 | |
| SCHEMBL19682715 | 0.77 | KLKB1 (0.57) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760622-A1 | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2021-01-06 | — | — | EP | disclosed |
| EP-3464271-B1 | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LTD (GB) | 2020-05-13 | — | — | EP | disclosed |