Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 15/20 | 0.85 |
| ▸ | KLKB1 | P03952 | 15/20 | 0.85 |
| ▸ | F2 | P00734 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21145581 | 0.92 | F11 (1.00) | F11KLKB1F2 | |
| SCHEMBL21145604 | 0.89 | KLKB1 (0.81) | F11KLKB1F2 | |
| SCHEMBL21145569 | 0.85 | KLKB1 (0.85) | F11KLKB1F2 | |
| SCHEMBL21985916 | 0.84 | F11 (0.77) | F11KLKB1F2 | |
| SCHEMBL19682714 | 0.84 | F11 (1.00) | F11KLKB1F2 | |
| SCHEMBL21145591 | 0.83 | F11 (1.00) | F11KLKB1F2 | |
| SCHEMBL21145595 | 0.83 | KLKB1 (1.00) | F11KLKB1F2 | |
| SCHEMBL21145557 | 0.81 | F11 (0.80) | F11KLKB1F2 | |
| SCHEMBL19668413 | 0.78 | KLKB1 (0.86) | F11KLKB1F2 | |
| SCHEMBL17785353 | 0.77 | KLKB1 (0.80) | F11KLKB1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464271-B1 | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LTD (GB) | 2020-05-13 | — | — | EP | disclosed |