Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18819887 | 0.79 | KDM4E (0.34) | KDM4ECDC7DBF4ALDH1A1 | |
| SCHEMBL19711568 | 0.75 | PNMT (0.38) | KDM4E | |
| SCHEMBL27380968 | 0.75 | KDM4E (0.38) | KDM4ECDC7DBF4HPGDALDH1A1 | |
| SCHEMBL22595561 | 0.74 | UHRF1 (0.40) | KDM4ECDC7DBF4HPGDALDH1A1 | |
| SCHEMBL19679254 | 0.74 | KDM4E (0.35) | KDM4ECDC7DBF4HPGDALDH1A1 | |
| SCHEMBL22890488 | 0.72 | KDM4E (0.42) | KDM4EHPGDALDH1A1 | |
| SCHEMBL16276753 | 0.70 | KDM4E (0.36) | KDM4ECDC7DBF4ALDH1A1 | |
| SCHEMBL25020899 | 0.67 | KDM4E (0.44) | KDM4EHPGDALDH1A1 | |
| SCHEMBL17208933 | 0.65 | DRD4 (0.35) | KDM4E | |
| SCHEMBL3800030 | 0.65 | DRD4 (0.37) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172214-B1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES AS CDK INHIBITORS AND USES THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2020-05-13 | — | — | EP | disclosed |