Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20343978 | 0.86 | GPR119 (0.36) | GPR119HTR2CSLC6A4ALDH1A1LMNA | |
| SCHEMBL20252434 | 0.83 | DPP4 (0.33) | GPR119PDE4BPDE4DCNR2 | |
| SCHEMBL20343967 | 0.75 | SMN1; SMN2 (0.40) | HTR2CSLC6A4ALDH1A1LMNAMAPT | |
| SCHEMBL20239258 | 0.74 | PDE4B (0.34) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL21985800 | 0.74 | SMN1; SMN2 (0.41) | HTR2CSLC6A4ALDH1A1LMNAMAPT | |
| SCHEMBL20344054 | 0.73 | HTR2C (0.34) | HTR2CSLC6A4ALDH1A1LMNAMAPT | |
| SCHEMBL20252430 | 0.71 | SMN1; SMN2 (0.36) | GPR119ALDH1A1PDE4BPDE4D | |
| SCHEMBL20252443 | 0.69 | GPR119 (0.32) | GPR119PDE4BPDE4D | |
| SCHEMBL16738676 | 0.69 | GPR119 (0.36) | GPR119ALDH1A1LMNA | |
| SCHEMBL20252433 | 0.68 | MAPK8 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298001-B1 | DGAT2 INHIBITORS | LILLY CO ELI (US) | 2020-05-13 | — | — | EP | disclosed |