⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29876248 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL20529733 | 0.97 | MAPK1 (0.39) | — | |
| SCHEMBL5785175 | 0.82 | HSP90AA1 (0.42) | — | |
| SCHEMBL881773 | 0.69 | — | — | |
| SCHEMBL23996471 | 0.67 | XDH (0.32) | — | |
| SCHEMBL10693005 | 0.67 | XDH (0.36) | — | |
| SCHEMBL71025 | 0.67 | — | — | |
| SCHEMBL25047169 | 0.67 | HSP90AA1 (0.35) | — | |
| SCHEMBL7536489 | 0.67 | HTT (0.38) | — | |
| SCHEMBL25207314 | 0.67 | RET (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1285 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12338246-B2 | Pyrazine derivative and application thereof in inhibiting SHP2 | SUZHOU GENHOUSE PHARMACEUTICAL CO., LTD. (CN) | 2025-06-24 | — | — | US | claimed |
| US-12319706-B2 | Organometallic compound, light-emitting device including the same, and electronic apparatus including the light-emitting device | SAMSUNG DISPLAY CO., LTD. (KR) | 2025-06-03 | — | — | US | claimed |
| CN-114195799-B | Pyrazine derivative and application thereof in inhibiting SHP2 | 勤浩医药（苏州）有限公司 | 2025-01-28 | — | — | CN | claimed |
| US-20240368213-A1 | COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS | SAGE THERAPEUTICS, INC. | 2024-11-07 | — | — | US | claimed |
| US-20240246959-A1 | BENZIMIDAZOLE DERIVATIVE AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD. (CN) | 2024-07-25 | — | — | US | claimed |
| CN-118027041-A | BTK inhibitor ring derivative and preparation method and pharmaceutical application thereof | 西藏海思科制药有限公司 | 2024-05-14 | — | — | CN | claimed |
| US-20240109900-A1 | AZABICYCLIC SHP2 INHIBITORS | PROMIDIS S.R.L. (IT) | 2024-04-04 | — | — | US | claimed |
| CN-117466884-A | Heterocyclic compounds or salts thereof as ATR kinase inhibitors, pharmaceutical compositions containing same and uses thereof | 德州大学系统董事会 | 2024-01-30 | — | — | CN | claimed |
| CN-112218631-B | Heterocyclic inhibitors of ATR kinase | 德州大学系统董事会 | 2023-12-22 | — | — | CN | claimed |
| EP-4288431-A1 | AZABICYCLIC SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2023-12-13 | — | — | EP | claimed |
| WO-2005016862-A1 | SUBSTITUTED ARYLALKANOIC ACID DERIVATIVE AND USE THEREOF | ASAHI KASEI PHARMA CORPORATION (JP) | 2005-02-24 | — | — | WO | claimed |
| US-20040152706-A1 | Pyrazolopyrazine compound pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2004-08-05 | — | — | US | claimed |
| US-20040152659-A1 | Method for the treatment of parkinson's disease comprising administering an A1A2a receptor dual antagonist | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2004-08-05 | — | — | US | claimed |
| WO-2002100864-A1 | PYRAZOLOPYRAZINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-19 | — | — | WO | claimed |
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | claimed |
| EP-1177797-A9 | NOVEL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-15 | — | — | EP | claimed |
| EP-1177797-A1 | NOVEL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-06 | — | — | EP | claimed |
| US-6309811-B2 | CONTAINING REACTION PRODUCT OF COUPLER, TIMING GROUP AND DEVELOPMENT INHIBITOR | EASTMAN KODAK COMPANY | 2001-10-30 | — | — | US | claimed |
| US-20010010895-A1 | COLOR PHOTOGRAPHIC ELEMENT CONTAINING NITROGEN HETEROCYCLE DERIVATIVE AND INHIBITOR RELEASING COUPLER | CITICORP NORTH AMERICA, INC., AS AGENT | 2001-08-02 | — | — | US | claimed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | claimed |