Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29691773 | 0.85 | MEN1 (0.74) | MEN1KMT2AMAPTALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL29550095 | 0.84 | MEN1 (0.73) | MEN1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL21987068 | 0.84 | MEN1 (0.72) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL9763711 | 0.84 | PKM (0.74) | MEN1KMT2AMAPTALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL1596692 | 0.82 | PKM (0.72) | MEN1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL631760 | 0.82 | MEN1 (0.70) | MEN1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL21987073 | 0.82 | MAPT (0.69) | MEN1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL21987023 | 0.82 | MAPT (0.69) | MEN1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL9640576 | 0.80 | KMT2A (0.67) | MEN1KMT2AMAPTALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL30041301 | 0.80 | MEN1 (0.68) | MEN1KMT2AMAPTALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020109233-A2 | TRMT2A INHIBITORS FOR USE IN THE TREATMENT OF POLYGLUTAMINE DISEASES | FORSCHUNGSZENTRUM JÜLICH GMBH FACHBEREICH PATENTE (R-P) (DE) | 2020-06-04 | — | — | WO | disclosed |
| EP-3659593-A1 | TRMT2A INHIBITORS FOR USE IN THE TREATMENT OF POLYGLUTAMINE DISEASES | Forschungszentrum Jülich GmbH/ Abteilung RP-PT (DE) | 2020-06-03 | — | — | EP | disclosed |