Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 19/20 | 0.45 |
| ▸ | CDC42BPB | Q9Y5S2 | 19/20 | 0.45 |
| ▸ | CDC42BPA | Q5VT25 | 5/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.39 |
| ▸ | STK3 | Q13188 | 1/20 | 0.39 |
| ▸ | MELK | Q14680 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.39 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21190173 | 0.92 | ROCK1 (0.43) | ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL21190142 | 0.91 | ROCK2 (0.42) | ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL21189975 | 0.89 | ROCK2 (0.40) | ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL21190153 | 0.84 | ROCK2 (0.41) | ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL21177471 | 0.84 | ROCK1 (0.39) | ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL21190038 | 0.83 | LRRK2 (0.43) | ROCK2ROCK1CDC42BPBSTK3LRRK2 | |
| SCHEMBL21190143 | 0.82 | ROCK2 (0.36) | ROCK2ROCK1CDC42BPBCDC42BPACDC7 | |
| SCHEMBL21189980 | 0.82 | ROCK2 (0.44) | ROCK2ROCK1CDC42BPBCDC42BPALRRK2 | |
| SCHEMBL21177228 | 0.81 | ROCK2 (0.44) | ROCK2ROCK1CDC42BPBCDC42BPA | |
| Hydrochloric Acid SCHEMBL21177443 | 0.81 | ROCK2 (0.44) | ROCK2ROCK1CDC42BPBCDC42BPA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200171030-A1 | DUAL INHIBITORS OF ALK5 AND P38A MAP KINASE | INTEGRAL BIOSCIENCES PRIVATE LTD (IN) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200171030-A1 | DUAL INHIBITORS OF ALK5 AND P38A MAP KINASE | MAP2K2, MAP2K5, MAP2K1 | ROCK2 160/4885ROCK1 159/4885CDC42BPB 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.